Gypenoside IV
ginsenoside rb3
CAS: 68406-26-8
Molecular Formula: C53H90O22
Gypenoside IV - Names and Identifiers
Gypenoside IV - Physico-chemical Properties
| Molecular Formula | C53H90O22 |
| Molar Mass | 1079.27 |
| Density | 1.42±0.1 g/cm3(Predicted) |
| Melting Point | 193～195℃ |
| Boling Point | 1117.1±65.0 °C(Predicted) |
| Specific Rotation(α) | (c, 1 in MeOH)+19.4 |
| Flash Point | 634.2°C |
| Solubility | DMSO:100 mg/mL (92.65 mM) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White powder |
| Color | White |
| pKa | 12.85±0.70(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Stability | Hygroscopic |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.621 |
| MDL | MFCD10566396 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from ginseng, Gynostemma pentaphyllum. |
| In vitro study | Ginsenoside Rb3 (0.1-10 μM) is tested for inhibition of tumor necrosis factor-α (TNF)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) luciferase reporter activity using a human kidney 293T cell-based assay. Ginsenoside Rb3 shows the significant activity with an IC 50 of 8.2 μM. Ginsenoside Rb3 also inhibits the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells have been treated with TNF-α (10 ng/mL). Ginsenoside Rb3 (0.1-10 μM) significantly increases cell viability and inhibits lactate dehydrogenase (LDH) release in a dose-dependent manner. PC12 cell viability as determined by MTT reduction is also markedly decreased after the cell is exposed to oxygen and glucose deprivation (OGD)/OGD-Rep. But, when the cells are pretreated with Ginsenoside Rb3 (0.1, 1, and 10 μM), OGD/OGD-Rep induced cell toxicity is significantly attenuated, which is concentration-dependently attenuated by Ginsenoside Rb3 treatment. The viabilities are raised to 52.8%±5.6%, 64.6%±5.7%, and 76.4%±8.8%, respectively, compared with the control group. |
| In vivo study | Ginsenosides Rb3 is a major compound isolated from Gynostemma pentaphyllum that holistically improves gut microenvironment and induces anti-polyposis in Apc Min/+ mice. Six-weeks-old mice are subjected to Rb3 treatment, before the appearance of the intestinal polyps. All the mice are monitored for food intake, water consumption, and weight changes. Throughout the experiment, no Rb3/Rd-associated weight loss in mice is observed. In addition, none of the treated mice show variations in food and water consumption. Whereas, the number and size of the polyps are effectively reduced by Rb3 treatments. |
Gypenoside IV - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | LZ5857000 |
| HS Code | 29389090 |
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View History
Gypenoside IV
ETHANOLAMINE pure
CPD2051
Ultrafloc 5100
OCTENYL ACETATE
1,2-PHENYLENE CHLOROPHOSPHATE
4-Hydroxy-4-methylheptadecanoic acid lactone
Copperpowderdendritic
phytochelatin 2
ETHANOLAMINE pure
CPD2051
Ultrafloc 5100
OCTENYL ACETATE
1,2-PHENYLENE CHLOROPHOSPHATE
4-Hydroxy-4-methylheptadecanoic acid lactone
Copperpowderdendritic
phytochelatin 2